Should this supplement be regulated? Or taken off the market? The Doctors discuss what you should know before taking Kratom.
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Holcombe I want to ask you a question is a follow-up because I actually hear you loud and clear when you say that, but here's where I get concerned with complete lack of regulation, 30 grams, it says and I don't even know what that means we don't know how much that is and I read the back there's.
No dosing in this I could go buy this at a convenience store.
And it just says do not use while operating a motor vehicle machinery.
If you're pregnant or nursing is pick it up, um.
And so these.
This is what what I get concerned with is not people necessarily using it in a way that does help them because clearly I don't want to take away from what Chris and Susan have experienced in your own particular path.
What I worry about is is this if I can go buys have no idea what's in it and and I'm a kid or an adult, quite frankly and I go pop a few of these and I end up under the bridge.
Think anybody here is opposed to control and oversight or selling to people under under-18 regulation.
So, but I think, if you go backwards, instead of forwards, you're going to have people buying illicit substances, they're, more dangerous and it's going to be counterproductive and dangerous, I'm, curious how far apart the two sides are because again, we're all hearing about this for the first time if you're not involved in this.
Most people never heard of it is the biggest battle regulation or do you all believe in regulation, I believe 100% that this needs to be regulated, I have a lot of experience in the supplement world.
You know, I did a documentary bigger stronger faster.
We went in studied all these supplements.
So your cause is it could be dangerous and is dangerous.
Being regulated I don't think it's like a documentary I used to run supplements for the FDA.
So that's, a nice experience.
These are all illegal products.
And when they're making claims to treat addiction to cure, chronic pain supplements don't do that.
So the notion that they're accepting.
And embracing regulation is somewhat laughable.
When they're talking, about addiction they're talking about chronic pain.
We have products for it like that in this country people they're called drugs.
And you know what people.
And if the data is that compelling on Cranham working then it's your to your advantage to submit that data for a full review by the federal agencies that have that charge, and they you know, those are scientific extra tickets.
How does the yeah, yeah, used to looked at supplement right? And it shouldn't be it's, not a supplement when you're looking to treat pain.
And again, even as a sub girl as a dietary side, there are requirements for safety that none of those companies.
Those companies made considerable amounts of money have invested in putting that forward everyone's hiding in the shadows.
Why? If it's that great wouldn't you come forward with it and I think it's worth pointing out the way supplements are regulated is that they're? Not supposed to make claims about treating disease.
Exact so I think I think the difference is that you're talking about treating pain and treating depression, which which are medical conditions.
Does it manage? These types of conditions we're, not talking about treating or very little disease, we're talking about your law we're talking about helping things we're talking about this as improving our health and well-being.
I would not be from came in last two years.
If no hats 15 have not we all psychosis has side effects.
Can do our detox QC everything every too much.
Yeah, one client coming in it's, not a it's, not a large amount.
You know, we get forty clients a month in our detox it's, not a large amounts of pregnant this.
When they do under drugs, we treat them the same as heroin or opiates, coming witness that offense ignore what you're saying I'm, not completely disagreeing with what you're saying and your personal experience.
But what I'm saying is, we need more information, yeah, well and that's and that's.
Why this debate is so compelling, because when you lack information you're making guesses and I feel like I'm up here on the stage and I came into this debate, completely open-minded and I feel like I still need more information from because I understand completely where you're coming from I'm drawn to the arguments that if there's absolutely no formal studies out there and we're, just having people wing it that's, scarcely, I think we can probably agree at least from the medical side that it sounds like there is potential, there's, definitely possibly a nice role for this.
But just it hasn't been adequately, studied.
We don't know the dosage we don't know, some of the other potential side effects interactions things that we like to know when we start to make car any that normal studies it's like you're, starting to tell her about studies at Ole Miss at the University of Massachusetts.
There are studies going on right now at Stanford University at Columbia, University, wait to get things in the food supply, even things like this I had to do six really substantial.
This is we're talking about replacing sugar they're talking about replacing opium, heroin so suboxone.
So again, I think this is a few names and we're told that they're, okay, another right and a drug that's, not as being called into question.
This country has laws we generally try to follow though use addition period if the framework doesn't allow for this in medicine supplement anything you put in your mouth for your body you're, looking for some physiological response.
Whether you take an antacid, you take a laxative.
You take Tylenol, but I think that sort of rigid approach is counterproductive and I think you're going to you can't measure the lives that will be lost.
If you withdraw this.
So I want to ask the three of you because addiction specialist and Daniel.
You've spent so much time dealing with these types of issues.
You have three individuals here whose lives have been, they say improved whether directly or indirectly by using this.
How do you move forward in a way that doesn't completely wreck their lives? Get the studies? And if this does prove to be beneficial in some way shape or form do it in the right way is there any path forward because that's where I'm not an expert I'm, not a regular I'm, just a doctor.
There is a path forward, Travis and it's pretty clear it's outlined, the Food, Drug Cosmetic deck.
If you're going to sell as a supplement one you're, not going to make these types of claims and two, there are studies that need to be done.
Those studies haven't been done the companies selling the products haven't reinvested in the science to show that these side effects, there's clearly questions of harm here.
So I think that given our structure that we don't want to put it just like three people have been helped there have people in harm.
So if there's potential for harm, we owe it to not just three Americans, but all Americans to make sure that that potential isn't real and that's, the basis of our laws.
And anyone who wants to sell a product should have to go through there's a special exemption.
My daughter also thinks that want to kiss her finger.
And she has a boo-boo that it helps it heal.
Well, my lips aren't getting approved by the FDA any time soon, no matter how much she believes that you.
At low doses, kratom acts as a stimulant, making users feel more energetic. At higher doses, it reduces pain and may bring on euphoria. At very high doses, it acts as a sedative, making users quiet and perhaps sleepy. Some people who practice Asian traditional medicine consider kratom to be a substitute for opium.What is kratom traditionally used for? ›
Traditionally, kratom was mostly used as a stimulant by Thai and Malaysian laborers and farmers to overcome the burdens of hard work. They chewed the leaves to make them work harder and provide energy and relief from muscle strains.What are the side effects of kratom for the heart? ›
Conclusion: Previously reported adverse cardiovascular events from Kratom use include tachycardia, hypertension, chest pain, conduction defects, QTc prolongation as well as cardiac arrest.Does kratom lower testosterone? ›
In summary, findings showed that regular kratom tea/juice consumption does not affect circulating testosterone, FSH, or LH levels in healthy male adults.What are the good benefits of kratom? ›
Benefits of kratom use
Kratom is most commonly used for the self-treatment of chronic and/or acute pain, anxiety, or depression, and also to boost energy and focus. This plant is also used to treat withdrawal symptoms from a prescription drug or illicit drug dependency.
While kratom is most commonly known for its affinity to opioid receptors, it also has affinity to serotonin and dopamine receptors [13,14], signaling its potential for treating depression, anxiety, and psychosis.What is the metabolism of kratom? ›
The metabolism of kratom alkaloids is primarily hepatic, with several cytochrome P450 (CYP) isoforms involved, including CYP3A4, with lesser contributions from CYP2D6 and CYP2C9 .Does kratom help with inflammation? ›
Data analysis suggested that kratom possesses some benefits such as stimulant and sedative effects as wells as antinociceptive effects. It seems to inhibit pro-inflammatory mediator release and vascular permeability and can enhance immunity.What are the properties of kratom? ›
Consumption of its leaves produces both stimulant effects (in low doses) and sedative effects (in high doses), and can lead to psychotic symptoms, and psychological and physiological dependence. Kratom leaves contain two major psychoactive ingredients (mitragynine and 7-hydroxymytragynine).Does kratom increase depression? ›
Kratom dependence and withdrawal appear similar to that of opioids, and may also lead to worsening depression and anxiety.
A number of deaths have been reported along with complications such as respiratory depression, cardiopulmonary arrest, torsade de pointes and seizures. Its various effects and potential are yet to be fully studied.Does kratom cause respiratory depression? ›
The sectors of the brain kratom impacts are pain relief and mood sectors, not the sector that produced euphoria and, most importantly, scientific evidence demonstrates that kratom does not cause respiratory depression like classic opioids, a common cause of fatal overdoses.What drug increases testosterone? ›
In men, clomiphene helps to increase the natural production of testosterone and sperm in the testes (Mbi Feh, 2022).What drug blocks testosterone? ›
Luteinizing hormone-releasing hormone (LHRH) agonists (also called LHRH analogs or GnRH agonists) are drugs that lower the amount of testosterone made by the testicles. Treatment with these drugs is sometimes called medical castration because they lower androgen levels just as well as orchiectomy.What pills block testosterone? ›
Luteinizing hormone-releasing hormone (LHRH) agonists: These medications stop the testicles from making testosterone. One example is leuprolide (Lupron, Eligard). Luteinizing hormone-releasing hormone (LHRH) antagonists: These medications stop the brain from signaling the testicles to make testosterone.Does kratom help with chronic pain? ›
Kratom may be an effective reliever for chronic pain by attaching to opioid receptors. One compound found in kratom, 7-hydroxymitragynine, is 13 times more potent than morphine. Although kratom targets opioid receptors just like morphine and codeine do, it is considered an atypical opioid.
Kratom was shown to have muscle relaxant, anti-inflammatory, analgesic, anorectic, and morphine-like effects in preclinical studies, but human data are sparse. Its stimulant effects are reported at lower doses (1–5 g), with sedative and pain-relieving activities at higher doses (5–15 g).